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The film tackles the theme of an alleged "2012 is the end of the world" superstition, and how seven couples would spend what could be their last day on earth ever. A die-hard fan Jane (Kathryn Bernardo) wins tickets to Billy Fernandez's (Daniel Padilla) concert and meets the love of her life. A 40-year old virgin named Virgie (Pokwang) meets a gigolo Charles (Sam Milby). A hopeless, romantic secretary Barbara (Maja Salvador )is helping her boss Ken (Diether Ocampo) with "personal issues". Verna (Angelica Panganiban) who has been on holiday in Vietnam meets a waiter Elvis (John Lloyd Cruz). Belle (Bea Alonzo) is in love with gay, best-friend Butch (Zanjoe Marudo). A 35 year old, mentally-challenged Mike (Piolo Pascual) copes with two children (Zaijian Jaranilla and Xyriel Manabat. An active account-executive Patty (Kim Chiu) wants Alvin (Gerald Anderson) to become a model for her company.